By Terry Wikle Shapiro
Stem mobile and Bone Marrow Transplantation
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Extra resources for A Clinical Guide to Stem Cell and Bone Marrow Transplantation
1 Depicts the organization of the HLA/MHC complex. ) F. HLA class II antigens include HLA*DRB1, *DRB3, *DRB4, *DRB5, *DQA1, *DQB1, *DPA1, and *DPB1 genes. These antigens are found mainly on B lymphocytes, macrophages, monocytes, and dendritic cells. In transplantation, the DR molecule is the most important of the class II antigens. 3 G. HLA class III antigens are involved in immune function, especially with the serum complement system. The role of class III antigens in transplantation is not well understood.
Nagel RL. The dilemma of marrow transplantation in sickle cell anemia. Seminars in Hematology. 1991;29:180–201. 14. Luckit J, Treleaven J. Leukemias and lymphomas. In: Treleaven J, Wiernik P, eds. Bone Marrow Transplantation. London, England: Mosby-Wolfe; 1995:63–76. 15. Sparano JA, Ciobanu N, Gucalp R. Solid tumors. In: Treleaven J, Wiernik P, eds. Bone Marrow Transplantation. London, England: Mosby-Wolfe; 1995:77–100. 16. Engelking C, Kalinowski B, eds. A Comprehensive Guide to Breast Cancer Treatment: Current Issues and Controversies.
Patient Evaluation 1, 2 A. Although much of the pretransplant work-up of the patient is standard among transplant centers, the evaluation of any individual patient must also include testing appropriate to the patient's diagnosis and disease staging. B. From the standpoint of the patient, the pretransplant work-up is essentially the same for allogeneic, autologous, and peripheral blood stem cell transplants. C. A complete medical history must be obtained with attention to previous treatment, chemotherapeutic regimens, response to chemotherapy, duration of remissions, and current status of disease.