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By George F. Vande Woude

Advances in melanoma study presents precious details at the intriguing and fast-moving box of melanoma examine. the following, once more, notable and unique experiences are awarded on a number of issues

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Cancer 4, 423–436. , and Tanabe, K. (2006). Cancer immunosuppression and autoimmune disease: Beyond immunosuppressive networks for tumour immunity. Immunology 119, 254–264. Kim, J. , Rasmussen, J. , and Rudensky, A. Y. (2007). Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191–197. , Reilly, R. , Jaffee, E. , and Tani, T. (2009). OX40 costimulation can abrogate Foxp3þ regulatory T cell-mediated suppression of antitumor immunity. Int. J. Cancer 125, 630–638.

CD4þ CD25þ T cells responding to serologically defined autoantigens suppress antitumor immune responses. Proc. Natl. Acad. Sci. USA 100, 10902–10906. , Old, L. , and Gnjatic, S. (2005). CD4þ CD25þ regulatory T cells control the induction of antigen-specific CD4þ helper T cell responses in cancer patients. Blood 106, 1008–1011. North, R. J. (1982). Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J. Exp. Med. 155, 1063–1074.

Depletion of CD25þ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun. 2, 1–12. , and Dardenne, M. (1984). Studies of the thymus in mice bearing the Lewis lung carcinoma. III. Possible mechanisms of tumor-induced thymic atrophy. Clin. Immunol. Immunopathol. 32, 316–325. Kerbel, R. , and Kamen, B. A. (2004). The anti-angiogenic basis of metronomic chemotherapy. Nat. Rev. Cancer 4, 423–436. , and Tanabe, K. (2006). Cancer immunosuppression and autoimmune disease: Beyond immunosuppressive networks for tumour immunity.

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