Download Advances in Cancer Research, Vol. 15 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.) PDF

By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

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1968133, is that the Santigen in the S'T- cells may be the result of derepression of the host cell genome by the virus. Duff and Rapp (1970b) recently demonstrated that sera from pregnant hamsters reacted specifically with SV40-transformed hamster cells, indicating the presence of some derepressed embryonic antigens on SV40-transformed cells. It was somewhat puzzling that the sera from pregnant hamsters did not react with cells transformed either by adenoviruses or by chemical carcinogens. Even if each tumor virus depresses only a specific region of the host cell chromosome, pregnant hamsters should be exposed to all these antigens during embryogenesis, The definite proof that the S reaction is due, altogether or in part, to an embryonic antigen is still lacking, since no attempts have been made to determine whether anti-S sera will react with embryonic cells.

They concluded that none of the properties studied appeared to be a valid in vitro criterion for predicting tumorigenicity. , SV4O-transformed hamster cells, the in vitro properties of which could then be correlated with transplantability in vivo in weanling hamsters. I n contrast to the cells studied by Rabinowitz and Sachs which still contained polyoma T-antigen, the revertant cells studied by Marin and Macpherson (1969) appeared to have lost the viral genes present in the parental cells. The revertant cells were less tumorigenic and both polyoma-specific T- and transplantation antigens were lost or reduced.

Since TSTA and S-antigen(s) are both present a t the cell surface, there has been a temptation to assume that the in vitro tests are actually measuring TSTA. Tevethia et al. (1968b) were the first to point out the lack of relationship between TSTA and S-antigen in certain SV40exposed hamster cell lines which became oncogenic. The cell lines in question were derived by Diamandopoulos et al. (1968) by exposing cloned hamster embryo fibroblasts to SV40. Four of the seven virusexposed cell lines became oncogenic and developed SV40 S-antigen.

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