By Jesse P. Greenstein and Alexander Haddow
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The present yr (2004) marks the Silver Anniversary of the invention of the p53 tumor suppressor. The rising ? eld ? rst thought of p53 as a viral antigen after which as an oncogene that cooperates with activated ras in remodeling basic cells in tradition. Fueling the idea that of p53 appearing as a remodeling issue, p53 expression used to be markedly increased in a number of remodeled and tumorigenic phone traces in comparison to basic cells.
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Additional info for Advances in Cancer Research, Vol. 2
Elmore et al. (1948) noted a considerable increase in molecular weight with a 35 % solution of nucleic acid, whereas with solutions containing less than 1 % the reaction with mustard gas and HN2 is now thought to be intramolecular (see p. 26). Under biological conditions all the different reactions considered here can take place, and it is not inconceivable that they may occur simultaneously. I n this case some of the biological effects may possibly be produced by an inter- and others by an intramolecular reaction.
OSozcH~ I NO2 Epichlorhydrin l,bDifluor0-2~4-dinitrobensene l-Flur0-2~4-dinitrobenrene + +++ ++ +++ ++ ++ +++ +++ +++ +++ + activity. In the mesyloxy series those compounds which cannot inhibit tumor growth and which cannot form cyclic compounds (see p. 10) are amongst the best crosslinking agents examined. It is interesting that the aliphatic mustards fail to crosslink wool although they will crosslink soluble protein. The experiments with wool fibers do not, of course, constitute proof against the crosslinking hypothesis, although in the author’s opinion they detract from the support which had been deduced from the fact that the cytotoxic alkylating agents were all capable of crosslinking macromolecules in one system or another.
Although the effect of concentration on the reaction of deoxyribonucleic acid with mustard gas has not been determined systematically, a change-over from intra- to intermolecular reaction appears to occur as the concentration is increased. Elmore et al. (1948) noted a considerable increase in molecular weight with a 35 % solution of nucleic acid, whereas with solutions containing less than 1 % the reaction with mustard gas and HN2 is now thought to be intramolecular (see p. 26). Under biological conditions all the different reactions considered here can take place, and it is not inconceivable that they may occur simultaneously.